The Breakthrough Challenge
We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated over $3.1 million dollars to the ACC, funding 74 research projects. 100% of all participant-raised dollars are donated directly to cancer research.
Countdown to 2027 Registration
Our 2026 Fundraising Goal
$336,975
Raised of $300,000
Our 2025 Event Raised $350K!
Our Leaderboards
Top Fundraisers
Top Individuals (292)
View AllBo Ebby
$22,443.00 raised of $20,000.00
Bruce Levine
$18,900.00 raised of $20,000.00
David Wellborn
$16,190.00 raised of $20,000.00
Tina Wilson
$15,114.00 raised of $1,000.00
Kaethe Schumacher
$13,031.00 raised of $10,000.00
Top Teams (27)
View AllKeystone State Ride
$77,531.60 raised of $80,000.00
Team BC
$57,918.10 raised of $50,000.00
Team Zayde
$27,362.00 raised of $18,000.00
Mission Melanoma
$23,276.80 raised of $10,000.00
CARs Pedaling For Cures
$21,976.20 raised of $30,000.00
Donate To an Indvidual or a Team
Donate NowBreakthroughs in Action
Join Us to Make a Difference!
